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Trifluoroacetic acid → 5-(2-Fluoro-4-methanesulfonyl-phenyl)-2-piperidin-4-yl-furo[2,3-c]pyridine

HRID 1471768
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HRID 1471768 반응식
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[O:40][C:24]3=[CH:25][N:26]=[C:27]([C:29]4[CH:34]=[CH:33][C:32]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:31][C:30]=4[F:39])[CH:28]=[C:23]3[CH:22]=2)[CH2:17][CH2:16]1)=O)(C)(C)C.C([O-])(O)=O.[Na+]>ClCCl>[F:39][C:30]1[CH:31]=[C:32]([S:35]([CH3:38])(=[O:37])=[O:36])[CH:33]=[CH:34][C:29]=1[C:27]1[CH:28]=[C:23]2[CH:22]=[C:21]([CH:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]3)[O:40][C:24]2=[CH:25][N:26]=1
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참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 679735964-[5-(2-Fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 866945755-(2-Fluoro-4-methanesulfonyl-phenyl)-2-piperidin-4-yl-furo[2,3-c]pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (1.2 mL) is added to 4-[5-(2-fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (0.78 g) in dichloromethane (14 mL). The mixture is stirred at room temperature overnight. Aqueous NaHCO3 solution is added, the resulting mixture is stirred for 5 min, and the phases are separated. The aqueous phase is extracted with dichloromethane and the combined organic phases are washed with water and dried (Na2SO4). The solvent is evaporated to give the title compound. LC (method 1): tR=0.59 min; Mass spectrum (ESI+): m/z=375 [M+H]+.

후처리

  1. stirringthe resulting mixture is stirred for 5 min
  2. customthe phases are separated
  3. extractionThe aqueous phase is extracted with dichloromethane
  4. washthe combined organic phases are washed with water
  5. dry with materialdried (Na2SO4)
  6. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-a825771172d44fb8b737997021f612ab
출처 데이터셋
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09012456B2

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