[CH3:1][C:2]1([CH3:5])[O:4][CH2:3]1.[F:6][C:7]1[CH:12]=[C:11]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:10]=[CH:9][C:8]=1[C:17]1[CH:18]=[C:19]2[CH:25]=[C:24]([CH:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[O:23][C:20]2=[CH:21][N:22]=1>CO.ClCCl>[F:6][C:7]1[CH:12]=[C:11]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:10]=[CH:9][C:8]=1[C:17]1[CH:18]=[C:19]2[CH:25]=[C:24]([CH:26]3[CH2:31][CH2:30][N:29]([CH2:3][C:2]([CH3:5])([OH:4])[CH3:1])[CH2:28][CH2:27]3)[O:23][C:20]2=[CH:21][N:22]=11,1-Dimethyloxirane (55 μL) is added to a solution of 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-piperidin-4-yl-furo[2,3-c]pyridine (0.15 g) in methanol (2 mL) and dichloromethane (3 mL) at room temperature. The solution is stirred at 50° C. overnight. The solution is concentrated to give the crude title compound that is used without further purification. LC (method 4): tR=0.98 min; Mass spectrum (ESI+): m/z=447 [M+H]+.
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