Sodium Carbonate → 3,6-Dichloro-5-{[3-fluoro-5-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine

HRID 1472106노트

반응식

HRID 1472106 반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[C:6](Cl)[N:7]=1.[F:10][C:11]1[CH:12]=[C:13]([SH:21])[CH:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1COCC1>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[C:6]([S:21][C:13]2[CH:14]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:16]=[C:11]([F:10])[CH:12]=2)[N:7]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 122624033,5,6-Trichloro-1,2,4-triazineHCID 670547273-Fluoro-5-(trifluoromethyl)thiophenol

생성물 1

HCID 866688233,6-Dichloro-5-{[3-fluoro-5-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3,5,6-trichloro-1,2,4-triazine (3 mmol) in dry THF (30 mL) at −78° C. under nitrogen atmosphere is added 3-fluoro-5-(trifluoromethyl)benzenethiol (3 mmol) and sodium carbonate (3 mmol). The reaction is allowed to reach room temperature and is stirred at room temperature until formation of the desired compound. The solvent is evaporated. The residue is suspended in water and extracted with CH2Cl2. The dichloromethane solution is dried over MgSO4 and evaporated. The residue is chromatographed on a silica gel column.

후처리

  1. customto reach room temperature

출처 및 근거

ORD 기록
ord-e599684a16034b8b98a7108bd3de8c07
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09012462B2

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