2-Nitro-6-(pyridin-2-yl)aniline → 3-(Pyridin-2-yl)benzene-1,2-diamine

HRID 1472184노트

반응식

HRID 1472184 반응식
[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[C:5]=1[NH2:6])([O-])=O>CCOC(C)=O.[Pd]>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:7]1[CH:8]=[CH:9][CH:10]=[C:4]([NH2:1])[C:5]=1[NH2:6]

참가 물질

4

반응물 1

HCID 130010352-Nitro-6-(pyridin-2-yl)aniline

생성물 1

HCID 224661493-(Pyridin-2-yl)benzene-1,2-diamine수율 103,000%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-nitro-6-(pyridin-2-yl)aniline (XCIX) (2.4 g, 0.01 mmol, 1 eq) in EtOAc (350 mL) was added Pd/C (1 g) and the mixture was stirred at room temperature overnight, filtered and then concentrated in vacuo, to give 3-(pyridin-2-yl)benzene-1,2-diamine (1.9 g, 10.3 mmol, 89% yield) as a yellow oil. ESIMS found for C11H1N3 m/z 186 (M+H).

후처리

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-bbdcf91468af41a6972bbdb24702f3e4
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09012472B2

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