Tetrahydrofuran → HCID 14738110, 화합물

HRID 1472233노트

반응식

HRID 1472233 반응식
O1CCCC1.[CH3:6][C:7]([CH3:13])([CH:11]=[CH2:12])[CH2:8][CH2:9][OH:10].C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>O>[CH3:6][C:7]([CH3:13])([CH:11]=[CH2:12])[CH2:8][CH2:9][O:10][S:22]([CH3:21])(=[O:24])=[O:23]

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 125790984-Penten-1-ol, 3,3-dimethyl-

생성물 1

HCID 14738110HCID 14738110, 화합물수율 94%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a tetrahydrofuran (30 ml) solution of 3,3-dimethyl-4-penten-1-ol (3.6 g), triethylamine (4.1 g) and methanesulfonyl chloride (4.3 g) were added at 0° C., followed by raising the temperature to room temperature and further stirring for 30 minutes. Water was added thereto and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated saline solution, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure to obtain a crude product (5.7 g) of methanesulfonic acid 3,3-dimethyl-4-pentenyl ester. This crude product was subjected to a subsequent reaction without being purified.

후처리

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated saline solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-117e12157de34d1da4edde71378d2972
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09012493B2

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