Urea → 6-METHOXYQUINAZOLINE-2,4-DIOL

HRID 1472718노트

반응식

HRID 1472718 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:13][C:14](N)=[O:15]>O>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:14](=[O:15])[NH:13][C:4]2=[O:6]

참가 물질

4

반응물 2

HCID 1176UreaHCID 2779305-Methoxyanthranilic acid

생성물 1

HCID 103302006-METHOXYQUINAZOLINE-2,4-DIOL수율 88.8%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
200 °C

실험 절차

A mixture of 2-amino-5-methoxybenzoic acid (5.00 g, 29.9 mmol) and urea (5.40 g, 90.0 mmol) was heated to 200° C. for 1 hour. The mixture was cooled to room temperature and diluted with H2O (50 mL), the mixture was filtered off and the precipitate was washed with H2O (10 mL), dried in vacuo to give the product (5.10 g, yield 88%).

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe mixture was filtered off
  3. washthe precipitate was washed with H2O (10 mL)
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-0e2959cd25884f7cb48f6ce16e6d964d
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09012646B2

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