Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → (R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | (R)-beta-aminophenethyl alcohol | HCID 2724025 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | (R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol | HCID 11030628 | — |
반응 단계
To a solution of (R)-2-amino-2-phenyl-ethanol (0.5 g, 3.64 mmol) in 2-propanol (40 mL) were added sodium carbonate (1 g, 9.48 mmol), 1,4-dibromobutane (0.57 mL, 4.74 mmol) and potassium iodide (catalytic) in succession, and the mixture was refluxed overnight. After filtration, the solvent was removed under reduced pressure and the crude was used without further purification (0.53 g, 76%). LCMS method: 2, RT: 2.27 min; MI: 191-193 [M+1].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09012633B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-da06d73d72ff407486fff7064a858cd0 |
| 출처 메모 | uspto-grants-2015_04 |