Trifluoroacetic acid → HCID 86678431, 화합물

HRID 1473718노트

반응식

HRID 1473718 반응식
C(OC([NH:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([OH:22])=[O:21])[C:10]([O:12]C(C)(C)C)=[O:11])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([O-:22])=[O:21])[C:10]([OH:12])=[O:11].[NH4+:8]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86678430HCID 86678430, 화합물

생성물 1

HCID 86678431HCID 86678431, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 1-tert-Butyl 6-hydrogen (2S)-2-[(tert-butoxycarbonyl)amino]-5-(3-fluoropropyl)-hexanedioate (57.0 mg, 0.15 mmol) and trifluoroacetic acid (0.5 mL) and dichloromethane (0.5 mL) was stirred at r.t. for 30 min. Then the mixture was concentrated under reduced pressure and the residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min).

후처리

  1. concentrationThen the mixture was concentrated under reduced pressure
  2. customthe residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min)

출처 및 근거

ORD 기록
ord-ff2856ec28f247b1be4d2534fe0048a4
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09017645B2

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