참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Dimethylacetamide | HCID 31374 | — |
| 반응물 | 3-Bromo-5-fluorobenzonitrile | HCID 2783330 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(3-Bromo-5-cyanophenyl)piperidine-4-carboxylic acid | HCID 59588189 | — |
반응 단계
A mixture of 3-bromo-5-fluorobenzonitrile (1.6 g, 7.8 mmol), piperidine-4-carboxylic acid (2.6 g, 12.0 mmol), triethylamine (4.0 mL, 28.5 mmol) and N,N-dimethylacetamide (1.5 mL) in a sealed tube was heated to 130° C. for 48 hr. The reaction mixture was diluted with EtOAc and water. The organic layer was separated, dried (MgSO4), and concentrated to give a crude reside which was purified by chromatography on silica gel (CH2Cl2/MeOH) to afford 1-(3-bromo-5-cyanophenyl)piperidine-4-carboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09018205B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_04 |
|---|
| ORD ID | ord-d29d1020a44143528ce1a4ffac2d4325 |
|---|
| 출처 메모 | uspto-grants-2015_04 |
|---|
