Thionyl Chloride → 8-(Chloromethyl)imidazo[1,2-a]pyridine

반응식

[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10]O)[C:5]=12.S(Cl)([Cl:14])=O>>[Cl:14][CH2:10][C:6]1[C:5]2[N:4]([CH:3]=[CH:2][N:1]=2)[CH:9]=[CH:8][CH:7]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 11029987Imidazo[1,2-a]pyridin-8-ylmethanol

생성물 1

HCID 216615828-(Chloromethyl)imidazo[1,2-a]pyridine

반응 조건

온도: 75 °C

실험 절차

A mixture of imidazo[1,2-a]pyridin-8-ylmethanol (800 mg) and excess thionyl chloride was stirred at 70-80° C. for 8 h. Excess thionyl chloride was removed under vacuum. The residue was then diluted with toluene and evaporated. This procedure was repeated 3 times.

후처리

customExcess thionyl chloride was removed under vacuum
additionThe residue was then diluted with toluene
customevaporated

출처 및 근거

ORD 기록: ord-76526a3247e240ae85b244aac7857c6b
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09018210B2

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