(R)-1-Benzyl-5-carboxy-2-pyrrolidinone → Ethyl 3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoate

HRID 1474152노트

반응식

HRID 1474152 반응식
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C@@H:9]1[C:14]([OH:16])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH2:18]([O:20][C:21](=[O:33])[CH:22]([OH:32])[CH:23]([NH3+:31])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH3:19]>>[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C@@H:9]1[C:14]([NH:31][CH:23]([CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH:22]([OH:32])[C:21]([O:20][CH2:18][CH3:19])=[O:33])=[O:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 23390401(R)-1-Benzyl-5-carboxy-2-pyrrolidinoneHCID 86644788HCID 86644788, 화합물

생성물 1

HCID 66644659Ethyl 3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoate

실험 절차

The reaction was carried out in analogy to reaction step 20.1 by reacting (R)-1-benzyl-5-oxopyrrolidine-2-carboxylic acid and 4-ethoxy-3-hydroxy-4-oxo-1-phenylbutan-2-aminium chloride. ESI-MS [M+H]+=425.2.

후처리

  1. customThe reaction was carried out in analogy to reaction step 20.1

출처 및 근거

ORD 기록
ord-67a54abdeb2d4ce09d31cc0813dcc15c
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018206B2

반응 노트

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