m-Chloroperbenzoic acid → 2-Fluoro-4-(oxiran-2-yl)benzonitrile

HRID 1474271노트

반응식

HRID 1474271 반응식
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([F:11])[CH:4]=1)=[CH2:2].C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[F:11][C:5]1[CH:4]=[C:3]([CH:1]2[CH2:2][O:20]2)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 219046072-Fluoro-4-vinylbenzonitrile

생성물 1

HCID 552965762-Fluoro-4-(oxiran-2-yl)benzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-ethenyl-2-fluorobenzonitrile (18.0 g, 122 mmol) in 200 mL of DCM was slowly added mCPBA (74.8 g, 367.347 mmol) in portions at 0° C. The mixture was warmed to room temperature and stirred overnight. The solution was washed with aqueous Na2SO3 until KI paper didn't change color. The organic layers was washed with brine and then concentrated. The residue was purified via column chromatography to give 2-fluoro-4-oxiran-2-ylbenzonitrile.

후처리

  1. customat 0° C
  2. washThe solution was washed with aqueous Na2SO3 until KI paper didn't change color
  3. washThe organic layers was washed with brine
  4. concentrationconcentrated
  5. customThe residue was purified via column chromatography

출처 및 근거

ORD 기록
ord-ac6d10d928394cc79a45aadde10521a9
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018211B2

반응 노트

불러오는 중…