3-Bromo-2,5-dimethylbenzoic acid → (3-bromo-2,5-dimethylphenyl)methanol

HRID 1474322노트

반응식

HRID 1474322 반응식
[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([CH3:11])[CH:10]=1

참가 물질

3

반응물 1

HCID 592382453-Bromo-2,5-dimethylbenzoic acid

생성물 1

HCID 10656303(3-bromo-2,5-dimethylphenyl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-bromo-2,5-dimethylbenzoic acid (3.5 g, 15 mmol) in anhydrous THF was added borane THF complex (1.0 M, 25 mL, 25 mmol) at 0, then the reaction was warmed to ambient temperature overnight. The reaction was quenched with MeOH and concentrated to afford (3-bromo-2,5-dimethylphenyl)methanol.

후처리

  1. customThe reaction was quenched with MeOH
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7493043f55034c139b232a4efd223ef5
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018211B2

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