sodium (1Z)-1-cyanoprop-1-en-2-olate → HCID 178467934, 화합물

HRID 1474445노트

반응식

HRID 1474445 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1[CH:12]=O.[C:14](/[CH:16]=[C:17](\[O-:19])/[CH3:18])#[N:15].[Na+]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1/[CH:12]=[C:16](/[C:17](=[O:19])[CH3:18])\[C:14]#[N:15]

참가 물질

3

반응물 2

HCID 23687916sodium (1Z)-1-cyanoprop-1-en-2-olateHCID 178434325HCID 178434325, 화합물

생성물 1

HCID 178467934HCID 178467934, 화합물

실험 절차

Following the procedure described for Example 2A, the title compound was prepared using 2.74 g (15.5 mmol) 6-fluoro-3-methyl-1H-indazole-5-carbaldehyde (Example 3A) and 2.6 g (24.8 mmol) sodium (1Z)-1-cyanoprop-1-en-2-olate to yield 1.6 g (42% of th.) of the crude product which was used in the next step without further purification.

출처 및 근거

ORD 기록
ord-f6acff18def84522b1f7b4d7010e104c
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018234B2

반응 노트

불러오는 중…