Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → Taxane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Menthol | HCID 1254 | — |
| 반응물 | Paclitaxel | HCID 36314 | — |
| 반응물 | Docetaxel | HCID 148124 | — |
| 반응물 | Larotaxel | HCID 6918260 | — |
| 반응물 | Cabazitaxel | HCID 9854073 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Glycerol | HCID 753 | — |
| 생성물 | Taxane | HCID 9548828 | — |
반응 단계
200 mg of an active drug (docetaxel, paclitaxel, cabazitaxel, or larotaxel) is weighed into a 5 mL volumetric flask. 2 g polysorbate 80 is added to the flask and votexed for 3 minutes. Then glycerol (0.5 g), polyvinylpyrrolidone (0.5 g), citric acid (0.05 g), menthol (0.025 g) are added to the flask. Ethanol is then added to make the total volume of 5 mL. The solution is votexed for 5 minutes and mixed well. The final pH is 5.3 (range 5.0-6.0).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09018246B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-5318a8c403df42548fa8f6d6c31fc5b4 |
| 출처 메모 | uspto-grants-2015_04 |