Citric Acid → Taxane

HRID 1474496

반응식

HRID 1474496 반응식
[CH3:1][C:2]1[C@@H:19](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C2C=CC=CC=2)=O)[CH2:18][C@:14]2(O)[C:15]([CH3:17])([CH3:16])[C:3]=1[C@@H:4](O)[C:5]([C@@:7]1([CH3:57])[C@H:12]([C@@H:13]2OC(C2C=CC=CC=2)=O)[C@:11]2(OC(C)=O)[CH2:50]O[C@@H:10]2[CH2:9][C@@H:8]1O)=O.CC1[C@@H](OC([C@H](O)[C@@H](NC(C2C=CC=CC=2)=O)C2C=CC=CC=2)=O)C[C@]2(O)C(C)(C)C=1[C@@H](OC(C)=O)C([C@@]1(C)[C@H]([C@@H]2OC(C2C=CC=CC=2)=O)[C@]2(OC(C)=O)CO[C@@H]2C[C@@H]1O)=O.CC1[C@@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C2C=CC=CC=2)=O)C[C@]2(O)C(C)(C)C=1[C@@H](OC)C([C@@]1(C)[C@H]([C@@H]2OC(C2C=CC=CC=2)=O)[C@]2(OC(C)=O)CO[C@@H]2C[C@@H]1OC)=O.CC1[C@@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C2C=CC=CC=2)=O)C[C@]2(O)C(C)(C)C=1[C@@H](OC(C)=O)C([C@@]13[C@H]([C@@H]2OC(C2C=CC=CC=2)=O)[C@]2(OC(C)=O)CO[C@@H]2C[C@@H]1C3)=O.C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C1(C)CCC(C(C)C)C(O)C1>C(O)C.OCC(CO)O>[CH3:50][C@H:11]1[C@H:12]2[CH2:13][C@H:14]3[C:15]([CH3:16])([CH3:17])[C@@H:3]([CH2:4][CH2:5][C@:7]2([CH3:57])[CH2:8][CH2:9][CH2:10]1)[C@H:2]([CH3:1])[CH2:19][CH2:18]3

참가 물질

9

반응물 6

HCID 311Citric AcidHCID 1254MentholHCID 36314PaclitaxelHCID 148124DocetaxelHCID 6918260156294-36-9HCID 9854073Cabazitaxel

생성물 1

HCID 9548828Taxane

시약·촉매·용매 2

HCID 702Ethanol용매HCID 753Glycerol용매

실험 절차

200 mg of an active drug (docetaxel, paclitaxel, cabazitaxel, or larotaxel) is weighed into a 5 mL volumetric flask. 2 g polysorbate 80 is added to the flask and votexed for 3 minutes. Then glycerol (0.5 g), polyvinylpyrrolidone (0.5 g), citric acid (0.05 g), menthol (0.025 g) are added to the flask. Ethanol is then added to make the total volume of 5 mL. The solution is votexed for 5 minutes and mixed well. The final pH is 5.3 (range 5.0-6.0).

후처리

  1. waitThe solution is votexed for 5 minutes
  2. additionmixed well

출처 및 근거

ORD 기록
ord-5318a8c403df42548fa8f6d6c31fc5b4
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018246B2

연결된 노트

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