Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-butyl 3-oxopyrrolidine-1-carboxylate → 3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-butyl 3-oxopyrrolidine-1-carboxylate | HCID 471360 | — |
| 반응물 | 3-(2-Chloropyrimidin-4-yl)aniline | HCID 59341023 | — |
| 생성물 | 3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86603246 | 70% |
반응 단계
Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-1fc235b6f85a43b4a99287ff419e95a2 |
| 출처 메모 | uspto-grants-2010_06 |