Tert-butyl 3-oxopyrrolidine-1-carboxylate → 3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 14745

반응식

HRID 14745 반응식
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([NH2:14])[CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1.[C:15]([O:19][C:20]([N:22]1[CH2:26][CH2:25][C:24](=O)[CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([N:22]1[CH2:26][CH2:25][CH:24]([NH:14][C:10]2[CH:11]=[CH:12][CH:13]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH2:23]1)=[O:21])([CH3:18])([CH3:16])[CH3:17]

참가 물질

3

반응물 2

HCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylateHCID 593410233-(2-Chloropyrimidin-4-yl)aniline

생성물 1

HCID 866032463-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester수율 70%

실험 절차

Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.

후처리

  1. customThe product was purified on silica gel using 1:1 ethyl acetate

출처 및 근거

ORD 기록
ord-1fc235b6f85a43b4a99287ff419e95a2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732444B2

연결된 노트

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