1-(Azetidin-1-yl)-2-[4-(benzyloxy)-2-methylphenyl]ethanone → 1-(Azetidin-1-yl)-2-(4-hydroxy-2-methylphenyl)ethanone

HRID 1474667노트

반응식

HRID 1474667 반응식
[N:1]1([C:5](=[O:22])[CH2:6][C:7]2[CH:12]=[CH:11][C:10]([O:13]CC3C=CC=CC=3)=[CH:9][C:8]=2[CH3:21])[CH2:4][CH2:3][CH2:2]1>C(O)C.[OH-].[OH-].[Pd+2]>[N:1]1([C:5](=[O:22])[CH2:6][C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:8]=2[CH3:21])[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 708190121-(Azetidin-1-yl)-2-[4-(benzyloxy)-2-methylphenyl]ethanone

생성물 1

HCID 708187231-(Azetidin-1-yl)-2-(4-hydroxy-2-methylphenyl)ethanone

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

1-(azetidin-1-yl)-2-[4-(benzyloxy)-2-methylphenyl]ethanone (440 mg, 1.490 mmol) was dissolved in ethanol (3 ml) and palladium hydroxide on carbon (20%) (105 mg, 0.149 mmol) added. The mixture was stirred under an atmosphere of hydrogen gas at RT overnight. The mixture was filtered and the filtrate concentrated under reduced pressure to afford the title compound. LC/MS (m/z): 206 (M+H)+.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-92b76a4414124e0bac97819365c60e29
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018224B2

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