2-(4-(benzyloxy)-2-methylphenyl)-N,N-dimethylacetamide → 2-(4-hydroxy-2-methylphenyl)-N,N-dimethylacetamide

HRID 1474670노트

반응식

HRID 1474670 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=[O:17])=[C:11]([CH3:21])[CH:10]=1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([N:18]([CH3:19])[CH3:20])=[O:17])=[C:11]([CH3:21])[CH:10]=1

참가 물질

4

반응물 1

HCID 708189752-(4-(benzyloxy)-2-methylphenyl)-N,N-dimethylacetamide

생성물 1

HCID 867111812-(4-hydroxy-2-methylphenyl)-N,N-dimethylacetamide

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

2-[4-(benzyloxy)-2-methylphenyl]-N,N-dimethylacetamide (680 mg, 2.40 mmol) was dissolved in ethanol (4 ml) and palladium hydroxide on carbon (20%) (169 mg, 0.240 mmol) added. The mixture was stirred under an atmosphere of hydrogen gas at RT overnight. The mixture was filtered and the filtrate concentrated under reduced pressure to afford the title compound. LC/MS (m/z): 194 (M+H)+.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e7ac5d08006a4faea82a24a549138e04
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018224B2

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