Ammonia → 3-Methyl-1H-1,2,4-triazole-5-carboxamide

HRID 1475221노트

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HRID 1475221 반응식
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9]CC)=O)[N:3]=1.[NH3:12]>CO>[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH2:12])=[O:9])[N:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 10464537ethyl 3-methyl-1H-1,2,4-triazole-5-carboxylate

생성물 1

HCID 122201083-Methyl-1H-1,2,4-triazole-5-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate (3.0 g, 19.3 mmol) is placed in a sealed tube that is then charged with a solution of 7N NH3 in MeOH (40 mL). The reaction is stirred at 50° C. for 24 h. The solvent was then removed under reduced pressure and the crude material was used directly for the next step without further purification. MS (ES+) C4H6N4O requires: 126. found: 127 [M+H]+.

후처리

  1. customThe solvent was then removed under reduced pressure
  2. customthe crude material was used directly for the next step without further purification

출처 및 근거

ORD 기록
ord-a9f6569fffba48f9b1af211c473f4130
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018380B2

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