Chlorosuccinimide → (Z)-N-hydroxy-4-(trifluoromethoxy)benzimidoyl chloride

HRID 1475260

반응식

HRID 1475260 반응식
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([CH:8]=[N:9][OH:10])=[CH:6][CH:5]=1.[Cl:15]N1C(=O)CCC1=O>CN(C=O)C>[OH:10]/[N:9]=[C:8](\[Cl:15])/[C:7]1[CH:11]=[CH:12][C:4]([O:3][C:2]([F:13])([F:14])[F:1])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 2777199p-Trifluoromethoxybenzaldehyde oxime

생성물 1

HCID 12096320(Z)-N-hydroxy-4-(trifluoromethoxy)benzimidoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-(trifluoromethoxy)benzaldehyde oxime (9.5 g, 46 mmol) in DMF (80 ml) was added N-chlorosuccinimide (8.0 g, 60 mmol) and the resulting mixture was stirred at RT for 5 h. The volatiles were removed under reduced pressure and the residue was dissolved in EtOAc, and washed with H2O, brine. The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure. The solid residue was used without further purification for the following step. 1H NMR (500 MHz, CDCl3) δ 7.78 (d, J=7.2 Hz, 2H), 7.13 (d, J=6.8 Hz, 2H).

후처리

  1. customThe volatiles were removed under reduced pressure
  2. dissolutionthe residue was dissolved in EtOAc
  3. washwashed with H2O, brine
  4. dry with materialThe organic layer was dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customThe solid residue was used without further purification for the following step

출처 및 근거

ORD 기록
ord-99c499aaafe343a1b83f74cf70c68bc8
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018380B2

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