참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 반응물 | Tri-tert-butylphosphine tetrafluoroborate | HCID 2734635 | — |
| 반응물 | 3-Chloro-4-methoxybenzeneboronic acid | HCID 3247522 | — |
| 반응물 | 3-Bromo-4-(trifluoromethyl)benzoic acid | HCID 22337570 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3'-Chloro-4'-methoxy-6-trifluoromethyl-biphenyl-3-carboxylic Acid | HCID 67170103 | — |
반응 단계
3-Bromo-4-trifluoromethyl-benzoic acid (0.484 g, 1.80 mmol), 3-chloro-4-methoxyphenylboronic acid (0.503 g, 2.70 mmol), tri-tert-butylphosphonium tetrafluoroborate (0.313 g, 1.08 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.494 g, 0.54 mmol) and potassium fluoride (0.345 g, 5.93 mmol) were weighed into a flask and dioxane (10 ml) was added under argon, and the mixture was stirred for 24 h at 50° C. The mixture was filtered over celite and evaporated to dryness. The residue was purified by preparative RP HPLC (water/ACN gradient) to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09018383B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_04 |
|---|
| ORD ID | ord-c04dae48045b4649b9170de709fa5306 |
|---|
| 출처 메모 | uspto-grants-2015_04 |
|---|
