HCID 86672573, 화합물 → 4-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl Ester

HRID 1475803노트

반응식

HRID 1475803 반응식
[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1

참가 물질

5

반응물 2

HCID 86672573HCID 86672573, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 671694814-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl Ester수율 99.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

250 mg of 4-((E)-2-Methanesulfonyl-vinyl)-3-(2-m-tolyl-ethoxy)-benzoic acid methyl ester were dissolved using 10 ml of methanol and hydrogenated under an 1.5 bar atmosphere of hydrogen using 50 mg of Pd/C (10%, 50% water) for 30 minutes. The catalyst was then removed by filtration and the solution evaporated to yield 250 mg of the title compound that was used without further purification.

후처리

  1. customThe catalyst was then removed by filtration
  2. customthe solution evaporated

출처 및 근거

ORD 기록
ord-d5e6544ed1e84e8e93f870acd9b345e3
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018383B2

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