tert-butyl N-hydroxycarbamate → [(tert-Butoxy)carbonyl]amino (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoate

HRID 1475996노트

반응식

HRID 1475996 반응식
[C:1]([O:5][C:6]([N:8]([CH3:14])[C@H:9]([CH3:13])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15]([O:19][C:20]([NH:22]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:1]([O:5][C:6]([N:8]([CH3:14])[C@H:9]([CH3:13])[C:10]([O:12][NH:22][C:20]([O:19][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:21])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 97534tert-butyl N-hydroxycarbamateHCID 16211306N-(tert-Butoxycarbonyl)-N-methyl-D-alanine

생성물 1

HCID 86654175[(tert-Butoxy)carbonyl]amino (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoate

실험 절차

[(tert-Butoxy)carbonyl]amino (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoate is prepared from (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoic acid and N-tert-butoxycarbonyl hydroxylamine according to Scheme 6. The compound exists as rotomers and is reported as such. (0.95 g, 60%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 7.81-7.95 (1H, m), 4.60-5.04 (1H, m), 2.85-2.93 (3H, m), 1.40-1.54 (18H, m), 1.22-1.33 (3H, m).

출처 및 근거

ORD 기록
ord-1d19402bc6ce4977a4acc8dcaf4165cd
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018411B2

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