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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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rac-Ethyl 2-[3-(benzylamino)-4-fluorophenyl]-trans-cyclopropanecarboxylate → rac-Ethyl 2-[3-amino-4-fluorophenyl]-trans-cyclopropanecarboxylate

HRID 1476068
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반응식

HRID 1476068 반응식
C([NH:8][C:9]1[CH:10]=[C:11]([C@@H:16]2[CH2:18][C@H:17]2[C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:12]=[CH:13][C:14]=1[F:15])C1C=CC=CC=1.[H][H]>C(O)C.C1COCC1.[Pd]>[NH2:8][C:9]1[CH:10]=[C:11]([C@@H:16]2[CH2:18][C@H:17]2[C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:12]=[CH:13][C:14]=1[F:15]
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참가 물질

5

반응물 2

HCID 123461582rac-Ethyl 2-[3-(benzylamino)-4-fluorophenyl]-trans-cyclopropanecarboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 123637899rac-Ethyl 2-[3-amino-4-fluorophenyl]-trans-cyclopropanecarboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

262 mg (purity 66%, 0.55 mmol) of (+/−)-ethyl 2-[3-(benzylamino)-4-fluorophenyl]-trans-cyclopropanecarboxylate were dissolved in 5 ml of ethanol/THF (1:1), 26 mg of palladium on carbon (10%) were added and the mixture was hydrogenated at RT using a hydrogen pressure of 1 bar for 24 h. The reaction mixture was then filtered through celite, the residue was washed with ethanol and the filtrate was concentrated. The crude product obtained in this manner was purified by preparative HPLC. This gave 87 mg (69% of theory) of the target compound.

후처리

  1. customwas hydrogenated at RT
  2. customfor 24 h
  3. filtrationThe reaction mixture was then filtered through celite
  4. washthe residue was washed with ethanol
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-0395c158f5d54612a9a55dfaa91fc24b
출처 데이터셋
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09018414B2

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