Potassium tert-butoxide → 1-Bromo-4-(1-fluorovinyl)benzene
반응식
CC(C)([O-])C.[K+].[Br:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([F:17])[CH2:15]Br)=[CH:10][CH:9]=1>CCCCC>[Br:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])=[CH2:15])=[CH:10][CH:9]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
796 mg (7.09 mmol) of potassium tert-butoxide were added in several portions to a solution, cooled to 0° C., of 1.0 g (3.55 mmol) of 1-bromo-4-(2-bromo-1-fluoroethyl)benzene in 10 ml of pentane. The resulting suspension was stirred at 0° C. for 30 min and then at RT for 1 h. The solid was filtered off, and the filtrate was washed with saturated ammonium chloride solution, dried over magnesium sulphate and carefully concentrated under reduced pressure. This gave 0.61 g (85.6% of theory) of the title compound.
후처리
- waitat RT for 1 h
- filtrationThe solid was filtered off
- washthe filtrate was washed with saturated ammonium chloride solution
- dry with materialdried over magnesium sulphate
- concentrationcarefully concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-2afb83c5d4ca4665a60dfc077f8087f7
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09018414B2
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