Trifluoroacetic acid → HCID 67259075, 화합물

HRID 1476610노트

반응식

HRID 1476610 반응식
[CH2:1]([N:3]1[N:7]=[C:6]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[S:17][C:13]=3[C:12](=[O:24])[N:11]([CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)[C:10]2=[O:38])[CH:5]=[N:4]1)[CH3:2].[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>C(Cl)Cl>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[CH2:1]([N:3]1[N:7]=[C:6]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[S:17][C:13]=3[C:12](=[O:24])[N:11]([CH:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[C:10]2=[O:38])[CH:5]=[N:4]1)[CH3:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67258405HCID 67258405, 화합물

생성물 1

HCID 67259075HCID 67259075, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of tert-butyl 4-{1-[(2-ethyl-2H-1,2,3-triazol-4-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (2.10 g; compound B21) in DCM (50 ml) is reacted with trifluoroacetic acid (10 ml) according to the procedure described in example B43 to afford the title compound as a solid.

출처 및 근거

ORD 기록
ord-d29b84cc97264cd08cde852cf6e50379
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018175B2

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