Ammonia methanol → 7-Chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxamide

HRID 1476818노트

반응식

HRID 1476818 반응식
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]([O:15]CC)=O)[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[NH3:18].CO>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]([NH2:18])=[O:15])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 21705897Ammonia methanolHCID 90386855Ethyl 7-chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

생성물 1

HCID 903871057-Chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxamide수율 38%

실험 절차

Ethyl 7-chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate (580 mg, 2.30 mmol) was dissolved in NH3/MeOH(4.0M, 15 mL) and the reaction mixture was stirred at RT overnight. The solvent was removed in vacuo. The resulting residue was washed with petroleum ether and dried to give the title compound (200 mg, 38%). ESI-MS m/z [M+H]+223.1.

후처리

  1. customThe solvent was removed in vacuo
  2. washThe resulting residue was washed with petroleum ether
  3. customdried

출처 및 근거

ORD 기록
ord-e9268d116d794627aca07daa61a2164a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09402841B2

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