Isoflurane → Fluasterone

HRID 1477069

반응식

HRID 1477069 반응식
C(Cl)(OC(F)F)C(F)(F)F.CNC1(C2C=CC=CC=2Cl)C(=O)CCCC1.CC1C=CC=C(C)C=1NC1SCCCN=1.CN1[C@@H]2C[C@@H](OC(C(C3C=CC=CC=3)CO)=O)C[C@H]1CC2.[CH3:63][C@@:64]12[C@H:73]3[CH2:74][CH2:75][C@:76]4([CH3:83])[C:80](=[O:81])[C@H:79]([F:82])[CH2:78][C@H:77]4[C@@H:72]3[CH2:71][CH:70]=[C:69]1[CH2:68][CH2:67][CH2:66][CH2:65]2.CCOCCOCCO>CC(C)=O>[CH3:63][C@@:64]12[C@H:73]3[CH2:74][CH2:75][C@:76]4([CH3:83])[C:80](=[O:81])[C@H:79]([F:82])[CH2:78][C@H:77]4[C@@H:72]3[CH2:71][CH:70]=[C:69]1[CH2:68][CH2:67][CH2:66][CH2:65]2

참가 물질

7

반응물 5

HCID 3763IsofluraneHCID 3821KetamineHCID 5707XylazineHCID 131736473Fluasterone carbitol3회HCID 178481186HCID 178481186, 화합물

생성물 1

HCID 133967Fluasterone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

The mice were anesthetized with Isoflurane, and then were given an intramuscular injection of 0.1 mL solution of ketamine (50 mg/kg), xylazine (10 mg/kg) and atropine (0.1 mg/kg). Approximately 10 minutes after the i.m. injection (after the mice could not turn over when placed on their backs), the mice were treated with 5 μL of a 12.5 mg/mL fluasterone/carbitol solution to give a dose of 2.5 mg/kg. The mice were anesthetized and on their backs for approximately 30 minutes after application of fluasterone/carbitol solution. One hour after the application of fluasterone/carbitol solution, 2 μg of TPA dissolved in 0.2 mL of acetone was applied to the shaved area on the back of each mouse.

후처리

  1. customApproximately 10 minutes
  2. customto give a dose of 2.5 mg/kg

출처 및 근거

ORD 기록
ord-6a6597a5e47a45a8a6936dbd1e09b78a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09402853B2

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