Isoflurane → Isopropyl Myristate

HRID 1477075

반응식

HRID 1477075 반응식
C(Cl)([O:6]C(F)F)C(F)(F)F.CN[C:13]1(C2C=CC=CC=2Cl)[C:18](=O)CCC[CH2:14]1.CC1C=CC=C(C)C=1NC1SCCCN=1.C[C@@:43]12[C@H:52]3[CH2:53][CH2:54][C@:55]4([CH3:62])[C:59](=[O:60])[C@H:58](F)[CH2:57][C@H:56]4[C@@H:51]3[CH2:50][CH:49]=[C:48]1[CH2:47]CCC2>C(O)C>[CH3:47][C:48]1[CH2:43][CH2:52][C@@H:51]([C:56]([CH3:57])=[CH2:55])[CH2:50][CH:49]=1.[C:59]([O:60][CH:13]([CH3:18])[CH3:14])(=[O:6])[CH2:58][CH2:57][CH2:56][CH2:51][CH2:50][CH2:49][CH2:48][CH2:43][CH2:52][CH2:53][CH2:54][CH2:55][CH3:62]

참가 물질

7

반응물 4

HCID 3763IsofluraneHCID 3821KetamineHCID 5707XylazineHCID 133967Fluasterone

생성물 2

HCID 8042Isopropyl MyristateHCID 440917(+)-Limonene

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The mice were anesthetized with Isoflurane, and then were given an intramuscular injection of 0.1 mL solution of ketamine (50 mg/kg) and xylazine (10 mg/kg). Approximately 10 minutes after the i.m. injection (after the mice could not turn over when placed on their backs), the mice were treated with 3.7 μL of a mg/mL fluasterone:ethanol:limonene:isopropyl myristate solution to give a dose of 1.5 mg/kg. The mice were anesthetized and on their backs for approximately 30 minutes after application of fluasterone:ethanol:limonene:isopropyl myristate solution. One hour after the application of fluasterone solution, 2 μg of TPA dissolved in 0.2 mL of acetone was applied to the shaved area on the back of each mouse.

후처리

  1. customApproximately 10 minutes

출처 및 근거

ORD 기록
ord-ed89a4e5c5c349d4a59969aedb35f484
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09402853B2

연결된 노트

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