Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodixanol → 5-Acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodixanol | HCID 3724 | — |
| 반응물 | Iohexol | HCID 3730 | — |
| 반응물 | 5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide | HCID 10395011 | — |
| 생성물 | 5-Acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide | HCID 11115326 | — |
반응 단계
In the acetylation step of the industrial scale synthesis of Iohexol and Iodixanol, 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound B) is acetylated to produce 5-acetylamino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound A) using acetic anhydride as the acetylating reagent. We have now found that Compound A can be prepared from Compound B in an optimized process wherein the generation of certain impurities is significantly reduced.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09403757B2 |
| 출처 데이터셋 | uspto-grants-2016_08 |
| ORD ID | ord-c56a76d4aa0a42eeb6f43570e650ee07 |
| 출처 메모 | uspto-grants-2016_08 |