Trifluoroacetic acid → HCID 61632462, 화합물

HRID 1477586노트

반응식

HRID 1477586 반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:7]=[CH:6][N:5]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[N:4]=1.FC(F)(F)C(O)=O>ClCCl>[F:22][C:2]([F:1])([F:21])[C:3]1[CH:7]=[CH:6][N:5]([CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[N:4]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 712265361-Piperidinecarboxylic acid, 4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester

생성물 1

HCID 61632462HCID 61632462, 화합물수율 127.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a dichloromethane solution (1.5 mL) of tert-butyl 4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]piperidine-1-carboxylate (150 mg, 0.50 mmol) synthesized in Reference Synthesis Example 33, trifluoroacetic acid (0.7 mL) was added at room temperature, and the resultant solution was stirred for 3 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and water was added to the concentrated reaction solution, followed by extraction from the resultant mixture with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound (140 mg, quantitative).

후처리

  1. additionwas added at room temperature
  2. customAfter completion of the reaction
  3. concentrationthe reaction solution was concentrated under reduced pressure and water
  4. additionwas added to the concentrated reaction solution
  5. extractionfollowed by extraction from the resultant mixture with ethyl acetate
  6. washThe organic layer was washed with brine
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-94a0f81f217243a6bf86df6525b05066
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403798B2

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