3-Pyridinecarboxaldehyde → [3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-pyridin-3-ylmethyl-amine

HRID 14776노트

반응식

HRID 14776 반응식
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[CH2:11][NH:12][CH2:13][CH3:14])[CH:5]=[CH:4][N:3]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]=O)[CH:19]=1>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[CH2:11][N:12]([CH2:13][CH3:14])[CH2:24][C:20]2[CH:19]=[N:18][CH:23]=[CH:22][CH:21]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 103713-PyridinecarboxaldehydeHCID 86603259[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amine

생성물 1

HCID 86603260[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-pyridin-3-ylmethyl-amine

실험 절차

Intermediate 22 was coupled with pyridine-3-carboxaldehyde following procedure E. LC-MS showed the product had the expected M+H+ of 339.

출처 및 근거

ORD 기록
ord-b79ffbcfe46d4fcb99be816f870ec14b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732444B2

반응 노트

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