2-Amino-3,3-dimethylbutan-1-ol → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (1-hydroxymethyl-2,2-dimethyl-propyl)-amide

HRID 1477783

반응식

HRID 1477783 반응식
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][CH:19]([C:22]([CH3:25])([CH3:24])[CH3:23])[CH2:20][OH:21]>>[OH:21][CH2:20][CH:19]([NH:18][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[C:22]([CH3:25])([CH3:24])[CH3:23]

참가 물질

3

반응물 2

HCID 41492122-Amino-3,3-dimethylbutan-1-olHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

생성물 1

HCID 715256665-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (1-hydroxymethyl-2,2-dimethyl-propyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and 2-amino-3,3-dimethyl-1-butanol (CAN 3907-02-6, 74.8 mg, 0.64 mmol) as starting materials, and isolated (40 mg, 28.16%) as light yellow sticky solid; LC-MS (UV peak area, ESI) 89.43%, 334.2 (M+H).

후처리

  1. customisolated (40 mg, 28.16%) as light yellow sticky solid

출처 및 근거

ORD 기록
ord-18b6bef4fcf74220a21d8fac20044836
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403808B2

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