N-((1,1-dimethylethoxy)carbonyl)-beta-alanine → 3-Amino-N-(3-{2-[2-(4-hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-propionamide
반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.C(OC([NH:31][CH2:32][CH2:33][C:34](O)=[O:35])=O)(C)(C)C>>[NH2:31][CH2:32][CH2:33][C:34]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH2:15][CH2:16][C:17]3[CH:18]=[CH:19][C:20]([OH:23])=[CH:21][CH:22]=3)[N:9]=2)[CH:3]=1)=[O:35]참가 물질
3
실험 절차
Intermediate 24 was coupled to 3-tert-butoxycarbonylamino-propionic acid by procedure K. The resulting product was deprotected by procedure G. LC-MS showed the product had the expected M+H+ of 377. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.6 (d, 1H) 8.4 (d, 1H) 8.1 (s, 1H) 7.8 (d, 1H) 7.5 (t 3H), 7.2 (d, 1H), 7.1 (d, 2H), 6.7 (d 2H), 3.6 (d, 2H), 3.1 (d, 2H), 2.8 (d, 2H), 2.5 (d, 2H).
출처 및 근거
- ORD 기록
- ord-48b228c66aff4d19b376d2b499654e40