Triacetoxyperiodinane → tert-butyl 1-[2-(4-chlorophenyl)-1-oxobutan-2-yl]-1H-indazol-4-ylcarbamate

HRID 1477856노트

반응식

HRID 1477856 반응식
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([N:35]2[C:43]3[C:38](=[C:39]([NH:44][C:45](=[O:51])[O:46][C:47]([CH3:50])([CH3:49])[CH3:48])[CH:40]=[CH:41][CH:42]=3)[CH:37]=[N:36]2)([CH2:33][CH3:34])[CH2:31][OH:32])=[CH:26][CH:25]=1>C(Cl)Cl>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([N:35]2[C:43]3[C:38](=[C:39]([NH:44][C:45](=[O:51])[O:46][C:47]([CH3:50])([CH3:49])[CH3:48])[CH:40]=[CH:41][CH:42]=3)[CH:37]=[N:36]2)([CH2:33][CH3:34])[CH:31]=[O:32])=[CH:26][CH:25]=1

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 70560487tert-butyl 1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-1H-indazol-4-ylcarbamate

생성물 1

HCID 86705040tert-butyl 1-[2-(4-chlorophenyl)-1-oxobutan-2-yl]-1H-indazol-4-ylcarbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of Dess-Martin periodinane (8.12 g, 19.15 mmol) in DCM (90 mL) at 0° C. was added a solution of tert-butyl 1-[2-(4-chlorophenyl)-1-hydroxybutan-2-yl]-1H-indazol-4-ylcarbamate (3.18 g, 7.67 mmol) in DCM (20 mL). The mixture was allowed to stir at rt for 2 hours. Then it was filtered and the filtrate was concentrated in vacuo to afford the crude product. The product was purified via column chromatography (0-10% EtOAc/hexanes) to provide the desired product.

후처리

  1. filtrationThen it was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. customto afford the crude product
  4. customThe product was purified via column chromatography (0-10% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-8c56e16632744f40a30ba7dbea43e773
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403807B2

반응 노트

불러오는 중…