methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate → methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

HRID 1477858노트

반응식

HRID 1477858 반응식
C(OC([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[N:12][N:13]2[C:18]([C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=1)([CH2:23][CH3:24])[C:19]([O:21][CH3:22])=[O:20])=O)(C)(C)C>Cl.CO>[NH2:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[N:12][N:13]2[C:18]([C:25]1[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=1)([CH2:23][CH3:24])[C:19]([O:21][CH3:22])=[O:20]

참가 물질

3

반응물 1

HCID 70562967methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

생성물 1

HCID 70561351methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

시약·촉매·용매 1

HCID 21893726Hydrochloride methanol용매

실험 절차

A mixture of methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate (3.0 g, 6.8 mmol), as described in Example 18 Step D, in 4 N HCl/MeOH (20 mL) was stirred at room temperature for 2 h. After removing the solvent, the residue was dissolved in ethyl acetate (80 mL), pH value adjusted to 9-10 with saturated sodium bicarbonate solution, dried over sodium sulfate, then filtered. After removing the organic solvent, the residue was used for the next step without purification. LC/MS m/z=344.1 [M+H]+.

후처리

  1. customAfter removing the solvent
  2. dissolutionthe residue was dissolved in ethyl acetate (80 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customAfter removing the organic solvent
  6. customthe residue was used for the next step without purification

출처 및 근거

ORD 기록
ord-04901881a1c543129ad0d340e7d55ea4
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403807B2

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