3-(Pyridin-3-yl)propanoic acid → N-(3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-3-pyridin-3-yl-propionamide

HRID 14779노트

반응식

HRID 14779 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[N:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][CH2:31][C:32](O)=[O:33])[CH:25]=1>>[OH:23][C:20]1[CH:19]=[CH:18][C:17]([CH2:16][CH2:15][NH:14][C:10]2[N:9]=[C:8]([C:4]3[CH:3]=[C:2]([NH:1][C:32](=[O:33])[CH2:31][CH2:30][C:26]4[CH:25]=[N:24][CH:29]=[CH:28][CH:27]=4)[CH:7]=[CH:6][CH:5]=3)[CH:13]=[CH:12][N:11]=2)=[CH:22][CH:21]=1

참가 물질

3

반응물 2

HCID 2596243-(Pyridin-3-yl)propanoic acidHCID 670450394-{2-[4-(3-Amino-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol

생성물 1

HCID 58603488N-(3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-3-pyridin-3-yl-propionamide

실험 절차

Intermediate 24 was coupled to 3-Pyridin-3-yl-propionic acid following procedure K. LC-MS showed the product had the expected M+H+ of 440. 1H NMR (Varian 300 MHz, DMSO-d6, shifts relative to the solvent peak at 2.49 ppm) δ 9.1 (s, 1H), 8.5 (d, 1H) 8.3 (d, 1H) 7.7 (m, 3H), 7.4 (t, 1H), 7.3 (t, 1H), 7.2 (d, 1H), 7.1 (d, 1H), 7.0 (d, 2H), 6.7 (d, 2H), δ 3.5 (t, 2H), 2.9 (t, 2H), 2.8 (t, 2H), δ 2.7 (t, 2H).

출처 및 근거

ORD 기록
ord-6e469e634f7046e39f0e79c8cdfd0dae
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732444B2

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