참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | 4'-Chloro-2'-fluoroacetanilide | HCID 853174 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | N-(4-chloro-2-fluoro-5-nitrophenyl)acetamide | HCID 13563753 | — |
반응 단계
A mixture of 4'-chloro-2'-fluoroacetanilide (51 g, 0.272 mol) in concentrated sulfuric acid (100 mL) is cooled to 0° C., treated with nitric acid (90% real, 14 mL, 0.300 mol) over 45 minutes, stirred for 10 minutes, and poured onto ice. The resultant aqueous mixture is filtered to obtain a tan solid which is washed with water, dried overnight, and recrystallized from a chloroform/hexanes (17:1) solution to give the title product as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05726126 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-b4cbb9aa494e49f7b3f195512e6252b9 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
