Triethylamine → HCID 118390102, 화합물

HRID 1478012노트

반응식

HRID 1478012 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[CH:4][N:3]=1.[NH2:10][CH:11]1[CH2:19][CH2:18][CH:17]2[CH:13]([CH2:14][N:15]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16]2)[CH2:12]1.CCN(CC)CC>CCO>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][CH:11]2[CH2:19][CH2:18][CH:17]3[CH:13]([CH2:14][N:15]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16]3)[CH2:12]2)[C:5]([Cl:9])=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2372592,4,5-TrichloropyrimidineHCID 83487964tert-butyl 5-amino-octahydro-1H-isoindole-2-carboxylate

생성물 1

HCID 118390102HCID 118390102, 화합물수율 126.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2,4,5-trichloropyrimidine (0.60 g, 3.27 mmol) and tert-butyl 5-aminohexahydro-1H-isoindole-2(3H)-carboxylate (2.79 g, 11.61 mmol) in EtOH (10 mL) was added Et3N (1.30 g, 12.84 mmol). After addition, the reaction mixture was stirred at rt overnight and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/5) to give the title compound as a pale yellow solid (1.60 g, 100%).

후처리

  1. additionAfter addition
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/5)

출처 및 근거

ORD 기록
ord-8d406dbfe6f844edb3022b74cba2c00c
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403801B2

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