Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethyl orthoformate → 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethyl orthoformate | HCID 9005 | — |
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| 생성물 | 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine | HCID 86603261 | — |
반응 단계
Intermediate 1 (3.69 g) was refluxed for two hours in trimethylorthoformate containing 10 mL of 4N HCl/dioxane. The solvent was removed by rotary evaporation to give product, which showed the expected M+H+ of 265 by LC-MS.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-7533bb8fdece41aa9e7946c5e94b613b |
| 출처 메모 | uspto-grants-2010_06 |