(4-Chloro-3-methoxy-2-pyridyl)-cyclopropyl-methanol → (4-Chloro-3-methoxy-2-pyridyl)cyclopropylketone

HRID 1478305노트

반응식

HRID 1478305 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]([CH:10]2[CH2:12][CH2:11]2)[OH:9])[C:3]=1[O:13][CH3:14]>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([CH:10]2[CH2:12][CH2:11]2)=[O:9])[C:3]=1[O:13][CH3:14]

참가 물질

4

반응물 1

HCID 68297213(4-Chloro-3-methoxy-2-pyridyl)-cyclopropyl-methanol

생성물 1

HCID 68297313(4-Chloro-3-methoxy-2-pyridyl)cyclopropylketone수율 96.2%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of (4-chloro-3-methoxy-2-pyridyl)-cyclopropyl-methanol (700 mg, 3.28 mmol) in DCM (20 ml), manganese (IV) oxide (4.6 g, 58 mmol) was added and stirred for 14 h at room temperature. The reaction mixture was filtered over Celite and the filtrate evaporated to dryness to obtain (4-chloro-3-methoxy-2-pyridyl)-cyclopropyl-methanone as a yellow oil (668 mg, 96%).

후처리

  1. filtrationThe reaction mixture was filtered over Celite
  2. customthe filtrate evaporated to dryness

출처 및 근거

ORD 기록
ord-55b8c47c09c344efa46f9c806f0d3c45
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403818B2

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