Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol | HCID 67045057 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde | HCID 86603262 | — |
반응 단계
Intermediate 27 (2.2 g) was treated with 30 mL of 3N HCl in 60 mL of CH3CN at room temperature overnight. The solvent was removed by rotary evaporation and the residue partitioned between ethyl acetate/sat. NaHCO3. Yield: 1.9 g, 99%. LC-MS showed the product had the expected M+H+ of 320.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-35af2987e5d84ed19c3e51c6c0d54461 |
| 출처 메모 | uspto-grants-2010_06 |