Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → Ethyl 3-amino-6-bromopicolinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | Ethyl 3-aminopyridine-2-carboxylate | HCID 565054 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl 3-amino-6-bromopicolinate | HCID 25137688 | — |
반응 단계
To a suspension of ethyl 3-aminopyridine-2-carboxylate (39.96 g, 241 mmol) in water (330 ml) was added H2SO4 (8 ml) and AcOH (16 ml). To this solution was added a solution of bromine in AcOH (84 ml) at ambient temperature under vigorous stirring so that the internal temperature remained around 25° C. After all bromine was added, stirring was continued for 1.5 h then the orange suspension was filtered giving ethyl 3-amino-6-bromo-pyridine-2-carboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09403845B2 |
| 출처 데이터셋 | uspto-grants-2016_08 |
| ORD ID | ord-be8199ea10ce466cab30937a4e63268c |
| 출처 메모 | uspto-grants-2016_08 |