Trifluoroacetic acid → (S)-2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine

HRID 1478558노트

반응식

HRID 1478558 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][C@H:17]4[O:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][C@H:17]4[O:22][CH2:21][CH2:20][NH:19][CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 118364809(S)-tert-butyl 2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine-4-carboxylate

생성물 1

HCID 118364740(S)-2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(S)-tert-butyl 2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine-4-carboxylate (21.9 g, 54.69 mmol) was dissolved in CH2Cl2 (300 ml), and TFA (5.3 g, 82.04 mmol) was added, followed by stirring at room temperature for 2 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure, and the next reaction was advanced.

후처리

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customthe next reaction

출처 및 근거

ORD 기록
ord-e08bd977fb8145b09175cdea6fa3e3dc
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403831B2

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