(S)-Tert-butyl 3-(azidomethyl)piperidine-1-carboxylate → tert-Butyl (3R)-3-(aminomethyl)piperidine-1-carboxylate
반응식
[N:1]([CH2:4][C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6]1참가 물질
4
실험 절차
(S)-tert-butyl 3-(azidomethyl)piperidine-1-carboxylate (5.38 g, 22.40 mmol) was dissolved in MeOH (50 ml), and then Pd/C (5% mol) was added, followed by stirring at room temperature under H2 (gas) for 9 hours. After the completion of the reaction, the reaction mixture was filtered through celite, followed by filtration and concentration under reduced pressure, and then the next reaction was advanced without purification.
후처리
- customAfter the completion of the reaction
- filtrationthe reaction mixture was filtered through celite
- filtrationfollowed by filtration and concentration under reduced pressure
- customthe next reaction
- customwas advanced without purification
출처 및 근거
- ORD 기록
- ord-f6fc61fefd43412c92d12202819e8678
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09403831B2
반응 노트
불러오는 중…