tert-Butyl methyl ether → 1-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

반응식

ClC1C=C(OC)C=CC=1N1C(C)=C(C(N[C:19]2[C:20](=[O:32])N(C3CCCCC3)N(C)[C:23]=2[CH3:24])=O)N=N1.[N:33]([C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=1)=[N+:34]=[N-:35].CC([O:47]C)(C)C>>[Cl:42][C:39]1[CH:40]=[CH:41][C:36]([N:33]2[C:23]([CH3:24])=[C:19]([C:20]([OH:32])=[O:47])[N:35]=[N:34]2)=[CH:37][CH:38]=1

참가 물질

반응물 3

HCID 15413tert-Butyl methyl ether

HCID 76803Benzene, 1-azido-4-chloro-

HCID 118513266HCID 118513266, 화합물

생성물 1

HCID 49799411-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

실험 절차

The title compound was prepared analogously to 1-(2-chloro-4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (Example 1 step 2) by replacing 1-azido-2-chloro-4-methoxybenzene with 1-azido-4-chlorobenzene in (0.5 M in TBME).

출처 및 근거

ORD 기록: ord-d06b40b8d36c4368a7d029b8d9c3ded8
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09403833B2

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