Borane → HCID 13142463, 화합물
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:13])[CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.B>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:13])[CH2:9][CH2:10][OH:11])=[CH:6][CH:7]=1참가 물질
4
실험 절차
To the solution of 3-(4-bromophenyl)butanoic acid (1 g, 4.1 mmol) in tetrahydrofuran (100 mL) was added borane in tetrahydrofuran (8 mL, 1 mol/L), the solution was stirred at reflux for 2 hours, then the solution was concentrated and purified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1) to give 3-(4-bromophenyl)butan-1-ol (791 mg, 84.6%).
후처리
- temperatureat reflux for 2 hours
- concentrationthe solution was concentrated
- custompurified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1)
출처 및 근거
- ORD 기록
- ord-97a3a9899218447d909cdcb5703a65c4
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09409865B2
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