p-Toluenesulfonic acid → HCID 89580873, 화합물
반응식
O1CCCCC1[O:7][CH2:8][CH2:9][CH:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)[CH3:11].C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[OH:7][CH2:8][CH2:9][CH:10]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:20][CH:21]=1)[CH3:11]참가 물질
4
실험 절차
To the solution of methyl 4-(4-(tetrahydro-2H-pyran-2-yloxy)butan-2-yl)benzoate (501.8 mg 1.72 mmol) in methanol (60 mL) was added p-toluenesulfonic acid (592 mg, 3.44 mmol). the solution was stirred for 12 hours, then the solvent was remove and dissolved in dichloromethane (50 ml) and washed water, dried with sodium sulfate, concentrated to give methyl 4-(4-hydroxybutan-2-yl)benzoate (354 mg, 99%).
후처리
- customthe solvent was remove
- dissolutiondissolved in dichloromethane (50 ml)
- washwashed water
- dry with materialdried with sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-aacbe58e2ccc4079936916b77d3eef8e
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09409865B2
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